Home>Capabilities>Particle Engineering & Granulation

Micronization Services for Nutraceutical Ingredients

Micronization reduces ingredient particle size to meet a defined powder specification. Botanovance helps supplement, food and beverage manufacturers assess particle size reduction for ingredients, alongside granulation and powder-handling requirements. We coordinate material review, sample evaluation and documentation, with the processing route and achievable specifications confirmed for each project.

Match the Process to the Powder’s Next Step

Start with the problem in your production process: a coarse particle fraction, inconsistent filling, poor wetting or blend segregation. Micronization and granulation change powders in different ways. The following routes provide a starting point for technical review; availability and suitability require project-specific confirmation.
Production staff in protective clothing reviewing documents inside an ingredient manufacturing facility
Route to assess What it changes Key selection criteria
Micronization Reduces particles to a finer size distribution Feed properties, target distribution, temperature sensitivity and acceptable fines
Dry granulation Compacts powder, then sizes the compacted material into granules Compaction suitability, granule strength and downstream filling or compression
Wet granulation or agglomeration Builds larger particles using a granulating liquid, with drying as required Permitted formulation aids, moisture and heat sensitivity, and handling or wetting targets
Powder blending and density review Combines components and evaluates packing and fill-volume behavior Component proportions, segregation risk and restrictions on composition changes
The distinction between size reduction, compaction and agglomeration informs process selection.

Define Particle Size, Density and Flow Together

A particle-size target is more useful when paired with a measurement method and a processing requirement. We help clarify these fields before reviewing feasible specifications.
Production staff in protective clothing reviewing documents inside an ingredient manufacturing facility
Specification field What to agree
Particle-size distribution Target Dv10, Dv50 and Dv90 in µm, where appropriate, with the measurement method and wet or dry dispersion conditions
Fines and oversize Permitted fractions; for sieve specifications, the aperture, sieve standard and percentage passing
Bulk and tapped density Separate targets in g/mL, with the test method and sample conditioning
Powder flow The agreed test method and acceptance criterion, supported by filling or feeding evaluation where needed
Composition Active-content requirement, permitted carriers or binders, and limits on added components
Material sensitivity Moisture limits and restrictions on temperature or processing exposure
Dv10, Dv50 and Dv90 are the sizes below which 10%, 50% and 90% of the sample volume fall. A sieve passing result does not describe the full particle-size distribution.

Check Performance in the Intended Application

Production staff in protective clothing reviewing documents inside an ingredient manufacturing facility
Evaluate a representative sample under the conditions your production line will use. A finer powder can become more cohesive, while granules can generate fines if they break during handling.
  • Capsules and tablets: Check feeding consistency, fill-weight variation and granule integrity. Tablet projects may also need compression and disintegration evaluation.
  • Powder blends and premixes: Check uniformity after mixing and after transfer or filling, where segregation may become apparent.
  • Beverages and liquid systems: Assess wetting, dispersibility and settling at the intended concentration, pH, temperature and mixing conditions.
The sample review should identify whether the proposed physical specification addresses the original processing problem.

Provide the Inputs Needed for a Technical Review

Production staff in protective clothing reviewing documents inside an ingredient manufacturing facility
The most useful starting information depends on the proposed route:
  • Micronization: Ingredient identity, incoming specification, current particle-size data, target distribution and material sensitivities.
  • Granulation: Target granule size and density, permitted formulation aids, moisture limits and the next filling, compression or mixing step.
  • Blending or density adjustment: Component identities and proportions, the handling problem and any restrictions on changing the composition.
Include your expected order volume, packaging, target market and required delivery date. We use these details to coordinate feasibility review and define the proposed sample and processing scope.

Agree the Testing and Composition Before Ordering

Production staff in protective clothing reviewing documents inside an ingredient manufacturing facility
Confirm which incoming-material and processed-material checks are included. Depending on the ingredient and project, these may cover identity, assay, moisture, particle size, density and flow. Each required check needs an agreed method and acceptance limit.
Where a carrier or binder is proposed, confirm its identity, proportion, allergen status and effect on final active content. Botanovance coordinates available specifications, batch COAs and relevant certification records for the selected product and production route. Additional testing and documentation requirements are reviewed individually.

Frequently Asked Questions

Production staff in protective clothing reviewing documents inside an ingredient manufacturing facility

Achievable particle size depends on the material, feed condition, available process and measurement method. Send your target distribution for assessment. The achievable range must be confirmed for the selected ingredient and production route.

A smaller particle may dissolve faster under defined conditions, but micronization alone does not establish full water solubility or improved absorption. Confirm performance in the intended formulation. If you need a supplied soluble or dispersible grade, review the available water-soluble ingredient options.

These are confirmed for the selected material and processing scope. Quote factors include the target specification, batch size, trial work, formulation aids, testing and packaging. Material availability, processing schedules, sample approval and additional analysis can affect timing.

State in your inquiry whether you need a supplied ingredient grade or processing of customer-owned material. Material acceptance, handling requirements and the service scope must be confirmed before sending any material.

For an existing ingredient grade, start with its product specification and availability. Explore specialty ingredient formats for material sourcing. Use a particle-processing inquiry when you need a particular size, density or handling requirement assessed.