










| Format | Main selection question | Evidence to request |
|---|---|---|
| Liposomal | Does the delivery architecture fit the intended use? | Composition and structural characterization |
| Water-soluble | How does the grade behave in the aqueous phase? | Dissolution or dispersion tests with stated conditions |
| Microencapsulated | Does the carrier system deliver the required function? | Protection, sensory or release testing |
| Granulated | Does the material suit the production operation? | Particle properties and processing trials |




Compare the cost of delivering the required active amount, alongside usable yield and processing requirements. A price per kilogram can be misleading when grades differ in assayed content, carrier contribution or inclusion level. Compare quotations against the same approved application brief.
A replacement requires evaluation because composition, density, carrier contribution and processing behavior may change. Recalculate the inclusion level using the supplied grade’s assay, then review unit size, ingredient declarations and performance in the finished recipe before approving the substitution.
No. Dissolution, physical protection and processing performance do not independently prove improved absorption. Such claims need evidence relevant to the particular active, preparation and use conditions. Evaluate the measured manufacturing properties separately from any proposed biological performance claim.
One grade may be a candidate for several products, but approval should be application-specific. A capsule trial does not establish behavior during gummy cooking or liquid storage. Define separate acceptance criteria for each product and document the corresponding evaluation results.
Begin with the active compound, intended product and manufacturing constraint. Include the required dose, carrier restrictions and relevant processing conditions. These details provide a basis for comparing candidate formats without committing to a technology before its suitability has been assessed.